| Reaction Details |
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 | Report a problem with these data |
| Target | Transitional endoplasmic reticulum ATPase |
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| Ligand | BDBM50158906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1566351 (CHEMBL3789455) |
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| IC50 | 240±n/a nM |
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| Citation |  Alverez, C; Arkin, MR; Bulfer, SL; Colombo, R; Kovaliov, M; LaPorte, MG; Lim, C; Liang, M; Moore, WJ; Neitz, RJ; Yan, Y; Yue, Z; Huryn, DM; Wipf, P Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. ACS Med Chem Lett6:1225-30 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transitional endoplasmic reticulum ATPase |
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| Name: | Transitional endoplasmic reticulum ATPase |
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| Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 89300.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55072 |
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| Residue: | 806 |
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| Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
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| BDBM50158906 |
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| n/a |
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| Name | BDBM50158906 |
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| Synonyms: | CHEMBL3785307 | US11247985, Table 3.123 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41N5 |
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| Mol. Mass. | 459.6693 |
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| SMILES | CC(C)N1CCN(CCNC2CCN(CC2)c2cccc(c2)-c2cc3cc(C)ccc3[nH]2)CC1 |
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| Structure | 
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