| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM60622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1566109 (CHEMBL3791993) |
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| IC50 | 4440±n/a nM |
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| Citation |  Brindisi, M; Maramai, S; Gemma, S; Brogi, S; Grillo, A; Di Cesare Mannelli, L; Gabellieri, E; Lamponi, S; Saponara, S; Gorelli, B; Tedesco, D; Bonfiglio, T; Landry, C; Jung, KM; Armirotti, A; Luongo, L; Ligresti, A; Piscitelli, F; Bertucci, C; Dehouck, MP; Campiani, G; Maione, S; Ghelardini, C; Pittaluga, A; Piomelli, D; Di Marzo, V; Butini, S Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem59:2612-32 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM60622 |
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| n/a |
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| Name | BDBM60622 |
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| Synonyms: | BDBM50300355 | US11753371, Compound JZL-184 | US9133148, A |
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| Type | n/a |
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| Emp. Form. | C27H24N2O9 |
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| Mol. Mass. | 520.4875 |
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| SMILES | OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1 |
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| Structure | 
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