| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50170725 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1577821 (CHEMBL3808055) |
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| IC50 | 14±n/a nM |
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| Citation |  Velthuisen, EJ; Johns, BA; Temelkoff, DP; Brown, KW; Danehower, SC The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors. Eur J Med Chem117:99-112 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50170725 |
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| n/a |
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| Name | BDBM50170725 |
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| Synonyms: | CHEMBL3805132 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17ClFN3O2 |
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| Mol. Mass. | 421.851 |
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| SMILES | [H][C@@]12CCCN1C(=O)c1c(O)c3ncc(Cc4cccc(Cl)c4F)cc3c(C#N)c1C2 |r| |
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| Structure | 
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