Ki Summary

Reaction Details

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Target

Cysteinyl leukotriene receptor 1

Ligand

BDBM58922

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1579540

IC50

310±n/a nM

Citation

Chen, H; Yang, H; Wang, Z; Xie, X; Nan, F Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists. ACS Med Chem Lett7:335-9 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cysteinyl leukotriene receptor 1

Name:

Cysteinyl leukotriene receptor 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38565.16

Organism:

Homo sapiens (Human)

Description:

Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271

Residue:

337

Sequence:

MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

BDBM58922

n/a

Name

BDBM58922

Synonyms:

MLS001304727 | MONTELUKAST Na | SMR000469188 | cid_23663996 | sodium;2-[1-[[(1R)-1-[3-[(E)-2-(7-chloranylquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-oxidanylpropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]ethanoate | sodium;2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate | sodium;2-[1-[[[(1R)-1-[3-[(E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]thio]methyl]cyclopropyl]acetate | sodium;2-[1-[[[(1R)-1-[3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]thio]methyl]cyclopropyl]acetate

Type

Small organic molecule

Emp. Form.

C35H35ClNO3S

Mol. Mass.

585.176

SMILES

CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC([O-])=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1

Structure