| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50180952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1585258 (CHEMBL3821389) |
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| IC50 | 179±n/a nM |
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| Citation |  von Kleist, L; Michaelis, S; Bartho, K; Graebner, O; Schlief, M; Dreger, M; Schrey, AK; Sefkow, M; Kroll, F; Koester, H; Luo, Y Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry. J Med Chem59:4664-75 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | LSS_RAT | Lss | Osc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83302.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12083 |
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| Residue: | 733 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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| BDBM50180952 |
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| n/a |
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| Name | BDBM50180952 |
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| Synonyms: | CHEMBL3818350 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10N2O6S |
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| Mol. Mass. | 310.283 |
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| SMILES | CCN1C(=O)S\C(=C\c2cc(O)c(O)c(c2)[N+]([O-])=O)C1=O |
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| Structure | 
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