| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Ligand | BDBM50384449 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1586735 (CHEMBL3825052) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Butler, KV; Bohn, K; Hrycyna, CA; Jin, J Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. Medchemcomm7:1016-1021 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31943.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_956034 |
|---|
| Residue: | 284 |
|---|
| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
|
|
|
|---|
| BDBM50384449 |
|---|
| n/a |
|---|
| Name | BDBM50384449 |
|---|
| Synonyms: | CHEMBL2035530 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31N3O2S |
|---|
| Mol. Mass. | 449.608 |
|---|
| SMILES | COC(=O)CCSC\C=C(/C)CCn1cc(CCc2ccc(cc2)-c2ccccc2)nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
