| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50183446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1586735 (CHEMBL3825052) |
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| IC50 | 18000±n/a nM |
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| Citation |  Butler, KV; Bohn, K; Hrycyna, CA; Jin, J Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. Medchemcomm7:1016-1021 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50183446 |
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| n/a |
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| Name | BDBM50183446 |
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| Synonyms: | CHEMBL3822563 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20O2S |
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| Mol. Mass. | 324.437 |
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| SMILES | Oc1c(ccc2ccccc12)C(C1CCOCC1)c1cccs1 |
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| Structure | 
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