| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
|---|
| Ligand | BDBM50192765 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1613700 (CHEMBL3855500) |
|---|
| Ki | 1600±n/a nM |
|---|
| Citation |  Ladziata, VU; Glunz, PW; Zou, Y; Zhang, X; Jiang, W; Jacutin-Porte, S; Cheney, DL; Wei, A; Luettgen, JM; Harper, TM; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg Med Chem Lett26:5051-5057 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vitamin K-dependent protein C |
|---|
| Name: | Vitamin K-dependent protein C |
|---|
| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52067.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 461 |
|---|
| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
|
|
|
|---|
| BDBM50192765 |
|---|
| n/a |
|---|
| Name | BDBM50192765 |
|---|
| Synonyms: | CHEMBL3895930 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H38FN5O6 |
|---|
| Mol. Mass. | 655.7152 |
|---|
| SMILES | C[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc1c(C)c3)c2)C1(CCOCC1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
