| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
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| Ligand | BDBM50199881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621769 (CHEMBL3864052) |
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| IC50 | 97±n/a nM |
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| Citation |  Ge, Y; Jin, Y; Wang, C; Zhang, J; Tang, Z; Peng, J; Liu, K; Li, Y; Zhou, Y; Ma, X Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a ACS Med Chem Lett7:1050-1055 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK |
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| Name: | Tyrosine-protein kinase BTK |
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| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76289.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187 |
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| Residue: | 659 |
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| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM50199881 |
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| n/a |
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| Name | BDBM50199881 |
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| Synonyms: | CHEMBL3962478 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N6O2 |
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| Mol. Mass. | 386.4066 |
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| SMILES | COc1ccc(Nc2ncc3ncn(-c4cccc(NC(=O)C=C)c4)c3n2)cc1 |
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| Structure | 
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