Reaction Details |
| Report a problem with these data |
Target | Coagulation factor VII/Tissue factor |
---|
Ligand | BDBM50201269 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1623064 (CHEMBL3865416) |
---|
Ki | 88.0±n/a nM |
---|
Citation | Wurtz, NR; Parkhurst, BL; Jiang, W; DeLucca, I; Zhang, X; Ladziata, V; Cheney, DL; Bozarth, JR; Rendina, AR; Wei, A; Luettgen, JM; Wu, Y; Wong, PC; Seiffert, DA; Wexler, RR; Priestley, ES Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors. ACS Med Chem Lett7:1077-1081 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor VII/Tissue factor |
---|
Name: | Coagulation factor VII/Tissue factor |
Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 69535 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Tissue factor |
Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
Type: | PROTEIN |
Mol. Mass.: | 33067.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_936735 |
Residue: | 295 |
Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
|
|
|
Component 2 |
Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
BDBM50201269 |
---|
n/a |
---|
Name | BDBM50201269 |
Synonyms: | CHEMBL3904281 |
Type | Small organic molecule |
Emp. Form. | C34H40N4O8S |
Mol. Mass. | 664.768 |
SMILES | COC(=O)Nc1ccc(c(c1)[C@H]1CCCN1C(=O)[C@H](Nc1ccc2C(C)NC(=O)c2c1)c1ccc(OC)c(OC)c1)S(=O)(=O)C(C)C |r| |
Structure |
|