| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease ATG4B |
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| Ligand | BDBM4078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628065 (CHEMBL3870650) |
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| IC50 | 5500±n/a nM |
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| Citation |  Cleenewerck, M; Grootaert, MOJ; Gladysz, R; Adriaenssens, Y; Roelandt, R; Joossens, J; Lambeir, AM; De Meyer, GRY; Declercq, W; Augustyns, K; Martinet, W; Van der Veken, P Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay. Eur J Med Chem123:631-638 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease ATG4B |
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| Name: | Cysteine protease ATG4B |
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| Synonyms: | APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44279.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_47132611 |
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| Residue: | 393 |
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| Sequence: | MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
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| BDBM4078 |
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| n/a |
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| Name | BDBM4078 |
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| Synonyms: | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione | CHEMBL6246 | ELLAGIC ACID | Elagic Acid | Ellagic acid (18) | Ellagic acid dihydrate | MLS000069632 | SMR000058244 | cid_5281855 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H6O8 |
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| Mol. Mass. | 302.1926 |
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| SMILES | Oc1cc2c3c(oc(=O)c4cc(O)c(O)c(oc2=O)c34)c1O |
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| Structure | 
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