| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50206210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628626 (CHEMBL3871211) |
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| IC50 | 1996±n/a nM |
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| Citation |  Petrilli, WL; Hoyt, SB; London, C; McMasters, D; Verras, A; Struthers, M; Cully, D; Wisniewski, T; Ren, N; Bopp, C; Sok, A; Chen, Q; Li, Y; Tung, E; Tang, W; Salituro, G; Knemeyer, I; Karanam, B; Clemas, J; Zhou, G; Gibson, J; Shipley, CA; MacNeil, DJ; Duffy, R; Tata, JR; Ujjainwalla, F; Ali, A; Xiong, Y Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension. ACS Med Chem Lett8:128-132 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM50206210 |
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| n/a |
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| Name | BDBM50206210 |
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| Synonyms: | CHEMBL3926792 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N3O |
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| Mol. Mass. | 295.3788 |
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| SMILES | CN1CC2(CC1=O)CCN(CC2)c1cncc2ccccc12 |
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| Structure | 
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