Reaction Details | |||
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Target | Metabotropic glutamate receptor 2 | ||
Ligand | BDBM50209108 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1633737 (CHEMBL3876529) | ||
EC50 | 0.400000±n/a nM | ||
Citation | Higgins, MA; Marcin, LR; Christopher Zusi, F; Gentles, R; Ding, M; Pearce, BC; Easton, A; Kostich, WA; Seager, MA; Bourin, C; Bristow, LJ; Johnson, KA; Miller, R; Hogan, J; Whiterock, V; Gulianello, M; Ferrante, M; Huang, Y; Hendricson, A; Alt, A; Macor, JE; Bronson, JJ Triazolopyridine ethers as potent, orally active mGlu Bioorg Med Chem25:496-513 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 2 | |||
Name: | Metabotropic glutamate receptor 2 | ||
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 95584.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14416 | ||
Residue: | 872 | ||
Sequence: |
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BDBM50209108 | |||
n/a | |||
Name | BDBM50209108 | ||
Synonyms: | CHEMBL3884532 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24F3N3O | ||
Mol. Mass. | 415.4514 | ||
SMILES | FC(F)(F)c1c(O[C@H]2CC[C@@H](CC2)c2ccccc2)ccn2c(CC3CC3)nnc12 |r,wU:10.13,wD:7.6,(11.67,-8.41,;12.88,-9.12,;12.63,-7.53,;11.37,-9.68,;14.21,-9.9,;14.21,-11.43,;12.87,-12.19,;12.86,-13.73,;11.51,-14.49,;11.5,-16.02,;12.82,-16.8,;14.16,-16.05,;14.18,-14.5,;12.8,-18.34,;11.46,-19.09,;11.44,-20.62,;12.77,-21.41,;14.11,-20.65,;14.12,-19.11,;15.54,-12.21,;16.87,-11.44,;16.88,-9.91,;18.02,-8.88,;19.53,-9.21,;20.62,-8.12,;21.02,-6.65,;22.11,-7.73,;17.41,-7.48,;15.88,-7.63,;15.55,-9.14,)| | ||
Structure |