Reaction Details | |||
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Target | Metabotropic glutamate receptor 2 | ||
Ligand | BDBM50209116 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1633737 (CHEMBL3876529) | ||
EC50 | 0.400000±n/a nM | ||
Citation | Higgins, MA; Marcin, LR; Christopher Zusi, F; Gentles, R; Ding, M; Pearce, BC; Easton, A; Kostich, WA; Seager, MA; Bourin, C; Bristow, LJ; Johnson, KA; Miller, R; Hogan, J; Whiterock, V; Gulianello, M; Ferrante, M; Huang, Y; Hendricson, A; Alt, A; Macor, JE; Bronson, JJ Triazolopyridine ethers as potent, orally active mGlu Bioorg Med Chem25:496-513 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 2 | |||
Name: | Metabotropic glutamate receptor 2 | ||
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 95584.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14416 | ||
Residue: | 872 | ||
Sequence: |
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BDBM50209116 | |||
n/a | |||
Name | BDBM50209116 | ||
Synonyms: | CHEMBL3883435 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H19F4N3O | ||
Mol. Mass. | 405.3887 | ||
SMILES | Fc1ccc(cc1)C1CC(C1)Oc1ccn2c(CC3CC3)nnc2c1C(F)(F)F |(14.5,-23.72,;14.51,-22.18,;13.18,-21.4,;13.19,-19.86,;14.53,-19.1,;15.86,-19.87,;15.85,-21.41,;14.54,-17.57,;13.46,-16.47,;14.56,-15.39,;15.64,-16.49,;14.57,-13.85,;15.92,-13.09,;17.25,-13.87,;18.58,-13.1,;18.59,-11.56,;19.73,-10.54,;21.24,-10.87,;22.33,-9.78,;22.74,-8.3,;23.83,-9.39,;19.12,-9.13,;17.58,-9.28,;17.26,-10.79,;15.92,-11.55,;14.59,-10.77,;13.37,-10.07,;14.34,-9.18,;13.07,-11.34,)| | ||
Structure |