Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Metabotropic glutamate receptor 2 | ||
Ligand | BDBM50209220 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1633737 (CHEMBL3876529) | ||
EC50 | 0.500000±n/a nM | ||
Citation | Higgins, MA; Marcin, LR; Christopher Zusi, F; Gentles, R; Ding, M; Pearce, BC; Easton, A; Kostich, WA; Seager, MA; Bourin, C; Bristow, LJ; Johnson, KA; Miller, R; Hogan, J; Whiterock, V; Gulianello, M; Ferrante, M; Huang, Y; Hendricson, A; Alt, A; Macor, JE; Bronson, JJ Triazolopyridine ethers as potent, orally active mGlu Bioorg Med Chem25:496-513 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 2 | |||
Name: | Metabotropic glutamate receptor 2 | ||
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 95584.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14416 | ||
Residue: | 872 | ||
Sequence: |
| ||
BDBM50209220 | |||
n/a | |||
Name | BDBM50209220 | ||
Synonyms: | CHEMBL3884187 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H20F3N3O | ||
Mol. Mass. | 387.3982 | ||
SMILES | FC(F)(F)c1c(OC2CC(C2)c2ccccc2)ccn2c(CC3CC3)nnc12 |(13.37,-10.07,;14.59,-10.77,;14.34,-9.18,;13.07,-11.34,;15.92,-11.55,;15.92,-13.09,;14.57,-13.85,;14.56,-15.39,;13.46,-16.47,;14.54,-17.57,;15.64,-16.49,;14.53,-19.1,;13.19,-19.86,;13.18,-21.4,;14.51,-22.18,;15.85,-21.41,;15.86,-19.87,;17.25,-13.87,;18.58,-13.1,;18.59,-11.56,;19.73,-10.54,;21.24,-10.87,;22.33,-9.78,;22.74,-8.3,;23.83,-9.39,;19.12,-9.13,;17.58,-9.28,;17.26,-10.79,)| | ||
Structure |