Reaction Details |
| Report a problem with these data |
Target | High affinity nerve growth factor receptor |
---|
Ligand | BDBM50232542 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1647981 (CHEMBL3997037) |
---|
IC50 | 2.7±n/a nM |
---|
Citation | Furuya, N; Momose, T; Katsuno, K; Fushimi, N; Muranaka, H; Handa, C; Ozawa, T; Kinoshita, T The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity. Bioorg Med Chem Lett27:1233-1236 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
High affinity nerve growth factor receptor |
---|
Name: | High affinity nerve growth factor receptor |
Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
Type: | n/a |
Mol. Mass.: | 87498.18 |
Organism: | Homo sapiens (Human) |
Description: | P04629 |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
|
|
|
BDBM50232542 |
---|
n/a |
---|
Name | BDBM50232542 |
Synonyms: | CHEMBL4090531 | US10323022, Example 135 |
Type | Small organic molecule |
Emp. Form. | C26H31F2N5O3 |
Mol. Mass. | 499.5528 |
SMILES | CCOc1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1 |r| |
Structure |
|