Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase PLK1

Ligand

BDBM50232581

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1648127

IC50

3.9±n/a nM

Citation

Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors. Bioorg Med Chem Lett27:1311-1315 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase PLK1

Name:

Serine/threonine-protein kinase PLK1

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

68277.16

Organism:

Homo sapiens (Human)

Description:

P53350

Residue:

603

Sequence:

MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS

BDBM50232581

n/a

Name

BDBM50232581

Synonyms:

CHEMBL4096151

Type

Small organic molecule

Emp. Form.

C36H47FN10O2

Mol. Mass.

670.8226

SMILES

CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2-n2cnc(C#N)c12 |r,wU:2.1,26.30,wD:23.23,(65.63,.49,;65.63,2.03,;64.3,2.79,;62.97,2.04,;62.96,.5,;61.62,-.27,;64.29,-.28,;61.65,2.82,;60.32,2.04,;58.99,2.81,;57.66,2.02,;57.66,.48,;58.99,-.28,;59,-1.82,;60.34,-2.58,;57.67,-2.6,;56.33,-1.83,;56.33,-.29,;54.99,.48,;54.99,2.02,;57.67,-4.14,;59.01,-4.9,;56.34,-4.91,;56.34,-6.45,;55.01,-7.22,;55.01,-8.75,;56.34,-9.53,;57.68,-8.75,;57.68,-7.21,;56.34,-11.06,;55.01,-11.82,;55,-13.36,;56.33,-14.13,;56.32,-15.67,;54.99,-16.44,;53.45,-16.43,;54.21,-17.77,;57.67,-13.37,;57.68,-11.82,;58.98,4.34,;60.31,5.12,;61.65,4.34,;62.98,5.12,;63.31,6.61,;64.83,6.75,;65.44,5.36,;66.95,5.02,;68.45,4.69,;64.3,4.34,)|

Structure