BindingDB PrimarySearch

Found 411 hits with Last Name = 'hosfield' and Initial = 'd'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM283216 (4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232582 (CHEMBL4067710) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM501809 (4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264020 (2-[5-[(4- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(cc1)C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM283129 (4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM283200 (4-[2-(4-amino-piperidin-1-yl)-5-(4- methoxyphenyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435724 (CHEMBL2392548) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435723 (CHEMBL2392549) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263974 (2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435732 (CHEMBL2392556) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264025 (2-(4-[2-(dimethylamino)ethyl]- 5-[(4- fluorophenyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264012 (2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232580 (CHEMBL4078098) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM501778 (4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232588 (CHEMBL4094634) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM283128 (4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM50554230 (CHEMBL4748670) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232583 (CHEMBL4074778) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232592 (CHEMBL4088932) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232579 (CHEMBL4103908) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232585 (CHEMBL4063398) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435734 (CHEMBL2392554) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435727 (CHEMBL2392545) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM50554231 (CHEMBL4796870) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM191600 (2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...) Show SMILES Cc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263992 (2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Br)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM285038 (4-(5-ethylsulfonyl-2-propoxyphenyl)-2-methyl- 6-(1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Curated by ChEMBL					Assay Description Inhibition of BRD4-BD1 in human Raji cells assessed as downregulation of MYC gene expression by PCR method				Bioorg Med Chem Lett 28: 1811-1816 (2018) Article DOI: 10.1016/j.bmcl.2018.04.016 BindingDB Entry DOI: 10.7270/Q20Z75WN
Celgene Quanticel Research Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50158627 (CHEMBL3787482 \| US10023592, Example 81) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Curated by ChEMBL					Assay Description Inhibition of BRD4-BD1 in human Raji cells assessed as downregulation of MYC gene expression by PCR method				Bioorg Med Chem Lett 28: 1811-1816 (2018) Article DOI: 10.1016/j.bmcl.2018.04.016 BindingDB Entry DOI: 10.7270/Q20Z75WN
Celgene Quanticel Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232584 (CHEMBL4074112) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232578 (CHEMBL4066163) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232590 (CHEMBL4101459) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263991 (2-{5-[(4-ethylbenzyl)oxy]- 1H-pyrazol-1-yl}pyridin...) Show SMILES CCc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM301089 (4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)py...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00978 BindingDB Entry DOI: 10.7270/Q2RJ4P33
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435728 (CHEMBL2392544) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM285038 (4-(5-ethylsulfonyl-2-propoxyphenyl)-2-methyl- 6-(1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Curated by ChEMBL					Assay Description Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...				Bioorg Med Chem Lett 28: 1811-1816 (2018) Article DOI: 10.1016/j.bmcl.2018.04.016 BindingDB Entry DOI: 10.7270/Q20Z75WN
Celgene Quanticel Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264025 (2-(4-[2-(dimethylamino)ethyl]- 5-[(4- fluorophenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5A (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50232581 (CHEMBL4096151) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of human FLAG-tagged PLK1 expressed in baculovirus infected sf21 cells using Biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 27: 1311-1315 (2017) Article DOI: 10.1016/j.bmcl.2016.10.009 BindingDB Entry DOI: 10.7270/Q2K939RQ
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264030 (2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264001 (2-{5-[(4-chloro-2- fluorobenzyl)oxy]-1H-pyrazol-1-...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)cc1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435735 (CHEMBL2392553) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263975 (2-{5-[(4-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263990 (2-{5-[(4-methylbenzyl)oxy]-1H- pyrazol-1-yl}pyridi...) Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264020 (2-[5-[(4- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(cc1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5A (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263978 (2-{5-[(4-methoxybenzyl)oxy]-1H- pyrazol-1-yl}pyrid...) Show SMILES COc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM50158703 (CHEMBL3785832 \| US10173996, Example 53 \| US9604961...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264021 (2-[5-[(4-chloro-2- phenylmethoxyphenyl)methoxy] py...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50435730 (CHEMBL2392558) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay				Bioorg Med Chem Lett 23: 3662-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.083 BindingDB Entry DOI: 10.7270/Q2ST7R8C
Takeda California Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263974 (2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM4C (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM285167 (2-methyl-6-(1-methylpyrazol-4-yl)-4-(5- methylsulf...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Curated by ChEMBL					Assay Description Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...				Bioorg Med Chem Lett 28: 1811-1816 (2018) Article DOI: 10.1016/j.bmcl.2018.04.016 BindingDB Entry DOI: 10.7270/Q20Z75WN
Celgene Quanticel Research Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50158627 (CHEMBL3787482 \| US10023592, Example 81) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Curated by ChEMBL					Assay Description Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...				Bioorg Med Chem Lett 28: 1811-1816 (2018) Article DOI: 10.1016/j.bmcl.2018.04.016 BindingDB Entry DOI: 10.7270/Q20Z75WN
Celgene Quanticel Research Curated by ChEMBL					More data for this Ligand-Target Pair

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