| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50235121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654664 (CHEMBL4004030) |
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| EC50 | 65±n/a nM |
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| Citation |  Harper, BH; Wang, L; Zhu, C; Kar, NF; Li, B; Moyes, CR; Goble, SD; Costa, M; Dingley, K; Di Salvo, J; Ha, SN; Hurley, A; Li, X; Miller, RR; Nagabukuro, H; Salituro, GM; Smith, S; Struthers, M; Hale, JJ; Edmondson, SD; Berger, R Investigation of piperazine benzamides as humanß Bioorg Med Chem Lett27:1094-1098 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50235121 |
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| n/a |
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| Name | BDBM50235121 |
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| Synonyms: | CHEMBL4066314 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33F3N6O2 |
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| Mol. Mass. | 542.5958 |
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| SMILES | [H][C@@]1(CC[C@@H](Cc2ccc(cc2)C(=O)N2CCN(Cc3ncn(CC(F)(F)F)n3)CC2)N1)[C@H](O)c1ccccc1 |r| |
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| Structure | 
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