| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase 1 |
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| Ligand | BDBM50235830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658127 (CHEMBL4007739) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett26:5562-5567 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase 1 |
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| Name: | cGMP-dependent protein kinase 1 |
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| Synonyms: | GMP-dependent protein kinase I | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | Protein Kinase G | cGMP-dependent protein kinase | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase 1 beta |
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| Type: | Protein |
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| Mol. Mass.: | 76358.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13976 |
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| Residue: | 671 |
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| Sequence: | MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR
AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY
PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT
VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET
HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV
RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF
NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI
IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD
YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS
ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP
PDDNSGWDIDF
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| BDBM50235830 |
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| n/a |
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| Name | BDBM50235830 |
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| Synonyms: | CHEMBL2006765 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F3N6O |
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| Mol. Mass. | 392.3783 |
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| SMILES | CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 |
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| Structure | 
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