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TargetFactor D
LigandBDBM203867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1658834
Kd 1600000±n/a nM
Citation Vulpetti ARandl SRüdisser SOstermann NErbel PMac Sweeney AZoller TSalem BGerhartz BCumin FHommel UDalvit CLorthiois EMaibaum J Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors. J Med Chem 60:1946-1958 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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  Blast E-value cutoff:
BDBM203867
n/a
NameBDBM203867
Synonyms:3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic acid (4)
TypeSmall organic molecule
Emp. Form.C17H14N2O4
Mol. Mass.310.3041
SMILESNC(=O)c1cc2cc(OCc3cccc(c3)C(O)=O)ccc2[nH]1
Structure
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