| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50237672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1662267 (CHEMBL4011948) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Irie, T; Asami, T; Sawa, A; Uno, Y; Hanada, M; Taniyama, C; Funakoshi, Y; Masai, H; Sawa, M Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem130:406-418 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
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| Type: | Protein |
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| Mol. Mass.: | 57322.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49759 |
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| Residue: | 484 |
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| Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
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| BDBM50237672 |
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| n/a |
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| Name | BDBM50237672 |
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| Synonyms: | CHEMBL4089159 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14ClN3O4 |
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| Mol. Mass. | 395.796 |
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| SMILES | COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4| |
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| Structure | 
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