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Compile Data Set for Download or QSAR

Found 71 hits with Last Name = 'funakoshi' and Initial = 'y'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237672
PNG
(CHEMBL4089159)
Show SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14ClN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-12(11)5-4-8-22-18)28-19(16)24-14-7-3-2-6-13(14)21/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 0.600n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123147
PNG
(US8742113, 239)
Show SMILES O=C1CC(OC1=Cc1c[nH]c2ncccc12)=Nc1ccc2[nH]ncc2c1 |w:6.7,16.19|
Show InChI InChI=1S/C19H13N5O2/c25-16-8-18(23-13-3-4-15-12(6-13)10-22-24-15)26-17(16)7-11-9-21-19-14(11)2-1-5-20-19/h1-7,9-10H,8H2,(H,20,21)(H,22,24)/b17-7-,23-18+
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n/an/a 1n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123148
PNG
(US8742113, 242)
Show SMILES Cc1ccsc1CN=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12 |w:14.16,7.7|
Show InChI InChI=1S/C18H15N3O2S/c1-11-4-6-24-16(11)10-20-17-8-14(22)15(23-17)7-12-9-21-18-13(12)3-2-5-19-18/h2-7,9H,8,10H2,1H3,(H,19,21)/b15-7-,20-17-
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n/an/a 1n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123146
PNG
(US8742113, 233)
Show SMILES Cc1cc(F)ccc1N=C1CC(=O)C(O1)=Cc1c[nH]c2ncccc12 |w:15.17,8.8|
Show InChI InChI=1S/C19H14FN3O2/c1-11-7-13(20)4-5-15(11)23-18-9-16(24)17(25-18)8-12-10-22-19-14(12)3-2-6-21-19/h2-8,10H,9H2,1H3,(H,21,22)/b17-8-,23-18+
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n/an/a 2n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123131
PNG
(US8742113, 15)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12 |w:19.21,11.12|
Show InChI InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,17H,2H2,1H3,(H,23,24)/b16-10-,25-20-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237689
PNG
(CHEMBL4066943)
Show SMILES COC(=O)C1=C(Nc2ccccc2F)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14FN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-12(11)5-4-8-22-18)28-19(16)24-14-7-3-2-6-13(14)21/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 2.40n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237692
PNG
(CHEMBL4091162)
Show SMILES COC(=O)C1=C(Nc2ccc(F)cc2F)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H13F2N3O4/c1-28-20(27)16-17(26)15(7-10-9-24-18-12(10)3-2-6-23-18)29-19(16)25-14-5-4-11(21)8-13(14)22/h2-9,25H,1H3,(H,23,24)/b15-7-
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n/an/a 2.5n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123142
PNG
(US8742113, 142)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCOCC1 |w:9.9,21.24|
Show InChI InChI=1S/C19H20N4O5/c1-2-27-19(25)15-16(24)14(28-18(15)22-23-6-8-26-9-7-23)10-12-11-21-17-13(12)4-3-5-20-17/h3-5,10-11,15H,2,6-9H2,1H3,(H,20,21)/b14-10-,22-18-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123144
PNG
(US8742113, 173)
Show SMILES COCCOC(=O)C1C(=O)C(OC1=Nc1ccccc1Cl)=Cc1c[nH]c2ncccc12 |w:21.23,13.14|
Show InChI InChI=1S/C22H18ClN3O5/c1-29-9-10-30-22(28)18-19(27)17(11-13-12-25-20-14(13)5-4-8-24-20)31-21(18)26-16-7-3-2-6-15(16)23/h2-8,11-12,18H,9-10H2,1H3,(H,24,25)/b17-11-,26-21-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123143
PNG
(US8742113, 157)
Show SMILES CC(C)OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(OCCO)cc1C |w:10.10,22.25|
Show InChI InChI=1S/C25H25N3O6/c1-14(2)33-25(31)21-22(30)20(12-16-13-27-23-18(16)5-4-8-26-23)34-24(21)28-19-7-6-17(11-15(19)3)32-10-9-29/h4-8,11-14,21,29H,9-10H2,1-3H3,(H,26,27)/b20-12-,28-24+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123137
PNG
(US8742113, 89)
Show SMILES OCCCOC(=O)C1C(=O)C(OC1=Nc1ccc(F)cc1)=Cc1c[nH]c2ncccc12 |w:21.23,13.14|
Show InChI InChI=1S/C22H18FN3O5/c23-14-4-6-15(7-5-14)26-21-18(22(29)30-10-2-9-27)19(28)17(31-21)11-13-12-25-20-16(13)3-1-8-24-20/h1,3-8,11-12,18,27H,2,9-10H2,(H,24,25)/b17-11-,26-21-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123140
PNG
(US8742113, 126)
Show SMILES CCOC(=O)C1C(=O)C(OC1=Nc1ccc(NCCO)cc1C)=Cc1c[nH]c2ncccc12 |w:23.25,11.12|
Show InChI InChI=1S/C24H24N4O5/c1-3-32-24(31)20-21(30)19(12-15-13-27-22-17(15)5-4-8-26-22)33-23(20)28-18-7-6-16(11-14(18)2)25-9-10-29/h4-8,11-13,20,25,29H,3,9-10H2,1-2H3,(H,26,27)/b19-12-,28-23+
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237682
PNG
(CHEMBL4083363)
Show SMILES COC(=O)C1=C(Nc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H15N3O4/c1-26-20(25)16-17(24)15(27-19(16)23-13-6-3-2-4-7-13)10-12-11-22-18-14(12)8-5-9-21-18/h2-11,23H,1H3,(H,21,22)/b15-10-
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n/an/a 3.30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237673
PNG
(CHEMBL4098085)
Show SMILES CCOC(=O)C1=C(Nc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:5|
Show InChI InChI=1S/C21H17N3O4/c1-2-27-21(26)17-18(25)16(28-20(17)24-14-7-4-3-5-8-14)11-13-12-23-19-15(13)9-6-10-22-19/h3-12,24H,2H2,1H3,(H,22,23)/b16-11-
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n/an/a 3.30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237695
PNG
(CHEMBL4072935)
Show SMILES COC(=O)C1=C(Nc2ccncc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C19H14N4O4/c1-26-19(25)15-16(24)14(27-18(15)23-12-4-7-20-8-5-12)9-11-10-22-17-13(11)3-2-6-21-17/h2-10H,1H3,(H,20,23)(H,21,22)/b14-9-
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n/an/a 3.5n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237701
PNG
(CHEMBL4098908)
Show SMILES COC(=O)C1=C(Nc2ccccc2C)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O4/c1-12-6-3-4-8-15(12)24-20-17(21(26)27-2)18(25)16(28-20)10-13-11-23-19-14(13)7-5-9-22-19/h3-11,24H,1-2H3,(H,22,23)/b16-10-
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n/an/a 3.80n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237702
PNG
(CHEMBL4070220)
Show SMILES COC(=O)C1=C(Nc2ccc(C)cc2C)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C22H19N3O4/c1-12-6-7-16(13(2)9-12)25-21-18(22(27)28-3)19(26)17(29-21)10-14-11-24-20-15(14)5-4-8-23-20/h4-11,25H,1-3H3,(H,23,24)/b17-10-
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n/an/a 3.90n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123149
PNG
(US8742113, 244)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCc2ccc(OC)cc2C1 |w:9.9,t:5|
Show InChI InChI=1S/C25H23N3O5/c1-3-32-25(30)21-22(29)20(12-16-13-27-23-19(16)5-4-9-26-23)33-24(21)28-10-8-15-6-7-18(31-2)11-17(15)14-28/h4-7,9,11-13H,3,8,10,14H2,1-2H3,(H,26,27)/b20-12-
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SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123134
PNG
(US8742113, 68)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc2c[nH]nc2c1 |w:9.9,21.24|
Show InChI InChI=1S/C22H17N5O4/c1-2-30-22(29)18-19(28)17(8-13-10-24-20-15(13)4-3-7-23-20)31-21(18)26-14-6-5-12-11-25-27-16(12)9-14/h3-11,18H,2H2,1H3,(H,23,24)(H,25,27)/b17-8-,26-21?
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n/an/a 4n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237698
PNG
(CHEMBL4090216)
Show SMILES COC(=O)C1=C(Nc2ccc3cn[nH]c3c2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H15N5O4/c1-29-21(28)17-18(27)16(7-12-9-23-19-14(12)3-2-6-22-19)30-20(17)25-13-5-4-11-10-24-26-15(11)8-13/h2-10,25H,1H3,(H,22,23)(H,24,26)/b16-7-
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n/an/a 4n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123138
PNG
(US8742113, 91)
Show SMILES CN(C)CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(F)cc1F |w:12.12,24.27|
Show InChI InChI=1S/C23H20F2N4O4/c1-29(2)8-9-32-23(31)19-20(30)18(10-13-12-27-21-15(13)4-3-7-26-21)33-22(19)28-17-6-5-14(24)11-16(17)25/h3-7,10-12,19H,8-9H2,1-2H3,(H,26,27)/b18-10-,28-22-
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n/an/a 4n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123139
PNG
(US8742113, 102)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCc2ccccc2C1 |w:9.9,t:5|
Show InChI InChI=1S/C24H21N3O4/c1-2-30-24(29)20-21(28)19(12-17-13-26-22-18(17)8-5-10-25-22)31-23(20)27-11-9-15-6-3-4-7-16(15)14-27/h3-8,10,12-13H,2,9,11,14H2,1H3,(H,25,26)/b19-12-
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n/an/a 4n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123145
PNG
(US8742113, 226)
Show SMILES O=C1CC(OC1=Cc1c[nH]c2ncccc12)=NC1CCCCCC1 |w:6.7,16.19|
Show InChI InChI=1S/C19H21N3O2/c23-16-11-18(22-14-6-3-1-2-4-7-14)24-17(16)10-13-12-21-19-15(13)8-5-9-20-19/h5,8-10,12,14H,1-4,6-7,11H2,(H,20,21)/b17-10-,22-18+
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n/an/a 4n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237690
PNG
(CHEMBL4084928)
Show SMILES COC(=O)C1=C(Nc2ccc(F)cc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14FN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-14(11)3-2-8-22-18)28-19(16)24-13-6-4-12(21)5-7-13/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 4.30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237688
PNG
(CHEMBL4091575)
Show SMILES COC(=O)C1=C(Nc2ccc(OC)cc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O5/c1-27-14-7-5-13(6-8-14)24-20-17(21(26)28-2)18(25)16(29-20)10-12-11-23-19-15(12)4-3-9-22-19/h3-11,24H,1-2H3,(H,22,23)/b16-10-
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n/an/a 4.90n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50237672
PNG
(CHEMBL4089159)
Show SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14ClN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-12(11)5-4-8-22-18)28-19(16)24-14-7-3-2-6-13(14)21/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 5n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123136
PNG
(US8742113, 81)
Show SMILES CCOC(=O)C1C(C=C(Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(OCCO)cc1F |w:21.24,t:7|
Show InChI InChI=1S/C24H22FN3O5/c1-2-32-24(31)21-20(28-19-6-5-16(12-18(19)25)33-9-8-29)11-14(22(21)30)10-15-13-27-23-17(15)4-3-7-26-23/h3-7,11-13,21,29H,2,8-10H2,1H3,(H,26,27)/b28-20-
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n/an/a 5n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))		BDBM50237672
PNG
(CHEMBL4089159)
Show SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14ClN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-12(11)5-4-8-22-18)28-19(16)24-14-7-3-2-6-13(14)21/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 5.30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237691
PNG
(CHEMBL4080872)
Show SMILES COC(=O)C1=C(Nc2ccc(C)cc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O4/c1-12-5-7-14(8-6-12)24-20-17(21(26)27-2)18(25)16(28-20)10-13-11-23-19-15(13)4-3-9-22-19/h3-11,24H,1-2H3,(H,22,23)/b16-10-
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n/an/a 5.90n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123133
PNG
(US8742113, 63)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCCCCC1 |w:9.9,t:5|
Show InChI InChI=1S/C21H23N3O4/c1-2-27-21(26)17-18(25)16(28-20(17)24-10-5-3-4-6-11-24)12-14-13-23-19-15(14)8-7-9-22-19/h7-9,12-13H,2-6,10-11H2,1H3,(H,22,23)/b16-12-
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n/an/a 6n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237686
PNG
(CHEMBL4062056)
Show SMILES COC(=O)C1=C(Nc2ccc(Cl)cc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14ClN3O4/c1-27-20(26)16-17(25)15(9-11-10-23-18-14(11)3-2-8-22-18)28-19(16)24-13-6-4-12(21)5-7-13/h2-10,24H,1H3,(H,22,23)/b15-9-
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n/an/a 6.70n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123151
PNG
(US8742113, 246)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCN(CC(F)(F)F)CC1 |w:9.9,21.24|
Show InChI InChI=1S/C21H22F3N5O4/c1-2-32-20(31)16-17(30)15(10-13-11-26-18-14(13)4-3-5-25-18)33-19(16)27-29-8-6-28(7-9-29)12-21(22,23)24/h3-5,10-11,16H,2,6-9,12H2,1H3,(H,25,26)/b15-10-,27-19+
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n/an/a 8n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123150
PNG
(US8742113, 245)
Show SMILES CC(C)OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=NN1CCOCC1 |w:10.10,22.25|
Show InChI InChI=1S/C20H22N4O5/c1-12(2)28-20(26)16-17(25)15(29-19(16)23-24-6-8-27-9-7-24)10-13-11-22-18-14(13)4-3-5-21-18/h3-5,10-12,16H,6-9H2,1-2H3,(H,21,22)/b15-10-,23-19-
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n/an/a 8n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237694
PNG
(CHEMBL4061554)
Show SMILES COC(=O)C1=C(Nc2cccnc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C19H14N4O4/c1-26-19(25)15-16(24)14(27-18(15)23-12-4-2-6-20-10-12)8-11-9-22-17-13(11)5-3-7-21-17/h2-10,23H,1H3,(H,21,22)/b14-8-
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n/an/a 8n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123141
PNG
(US8742113, 129)
Show SMILES CCOC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccc(CN(C)C)cc1C |w:9.9,21.24|
Show InChI InChI=1S/C25H26N4O4/c1-5-32-25(31)21-22(30)20(12-17-13-27-23-18(17)7-6-10-26-23)33-24(21)28-19-9-8-16(11-15(19)2)14-29(3)4/h6-13,21H,5,14H2,1-4H3,(H,26,27)/b20-12-,28-24+
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n/an/a 9n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237697
PNG
(CHEMBL4085578)
Show SMILES OC(=O)C1=C(Nc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:3|
Show InChI InChI=1S/C19H13N3O4/c23-16-14(9-11-10-21-17-13(11)7-4-8-20-17)26-18(15(16)19(24)25)22-12-5-2-1-3-6-12/h1-10,22H,(H,20,21)(H,24,25)/b14-9-
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n/an/a 9.90n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237675
PNG
(CHEMBL4087825)
Show SMILES COC(=O)C1=C(Nc2cc[nH]n2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C17H13N5O4/c1-25-17(24)13-14(23)11(26-16(13)21-12-4-6-20-22-12)7-9-8-19-15-10(9)3-2-5-18-15/h2-8H,1H3,(H,18,19)(H2,20,21,22)/b11-7-
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n/an/a 10n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123132
PNG
(US8742113, 22)
Show SMILES OC(=O)C1C(OC(=Cc2c[nH]c3ncccc23)C1=O)=Nc1ccccc1 |w:7.7,19.22|
Show InChI InChI=1S/C19H13N3O4/c23-16-14(9-11-10-21-17-13(11)7-4-8-20-17)26-18(15(16)19(24)25)22-12-5-2-1-3-6-12/h1-10,15H,(H,20,21)(H,24,25)/b14-9-,22-18-
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n/an/a 10n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM123135
PNG
(US8742113, 78)
Show SMILES CCOC(=O)C1=C(OC(=Cc2c[nH]c3ncccc23)C1=O)N1CCC(C)CC1 |w:9.9,t:5|
Show InChI InChI=1S/C21H23N3O4/c1-3-27-21(26)17-18(25)16(28-20(17)24-9-6-13(2)7-10-24)11-14-12-23-19-15(14)5-4-8-22-19/h4-5,8,11-13H,3,6-7,9-10H2,1-2H3,(H,22,23)/b16-11-
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US Patent
n/an/a 11n/an/an/an/a7.5n/a



SBI Biotech Co., Ltd.; Carna Biosciences, Inc.

US Patent


Assay Description
Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...

US Patent US8742113 (2014)


BindingDB Entry DOI: 10.7270/Q2B856S5
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237687
PNG
(CHEMBL4083793)
Show SMILES COC(=O)C1=C(Nc2ccccc2OC)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O5/c1-27-15-8-4-3-7-14(15)24-20-17(21(26)28-2)18(25)16(29-20)10-12-11-23-19-13(12)6-5-9-22-19/h3-11,24H,1-2H3,(H,22,23)/b16-10-
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n/an/a 12n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237699
PNG
(CHEMBL4060978)
Show SMILES COC(=O)C1=C(Nc2cccc(Cl)c2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C20H14ClN3O4/c1-27-20(26)16-17(25)15(8-11-10-23-18-14(11)6-3-7-22-18)28-19(16)24-13-5-2-4-12(21)9-13/h2-10,24H,1H3,(H,22,23)/b15-8-
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n/an/a 12n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237674
PNG
(CHEMBL4099816)
Show SMILES COC(=O)C1=C(Nc2cncnc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C18H13N5O4/c1-26-18(25)14-15(24)13(27-17(14)23-11-7-19-9-20-8-11)5-10-6-22-16-12(10)3-2-4-21-16/h2-9,23H,1H3,(H,21,22)/b13-5-
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n/an/a 18n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237677
PNG
(CHEMBL4062207)
Show SMILES COC(=O)C1=C(NCc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O4/c1-27-21(26)17-18(25)16(10-14-12-23-19-15(14)8-5-9-22-19)28-20(17)24-11-13-6-3-2-4-7-13/h2-10,12,24H,11H2,1H3,(H,22,23)/b16-10-
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n/an/a 23n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237700
PNG
(CHEMBL4070681)
Show SMILES COC(=O)C1=C(Nc2cccc(OC)c2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C21H17N3O5/c1-27-14-6-3-5-13(10-14)24-20-17(21(26)28-2)18(25)16(29-20)9-12-11-23-19-15(12)7-4-8-22-19/h3-11,24H,1-2H3,(H,22,23)/b16-9-
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n/an/a 29n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237693
PNG
(CHEMBL4083382)
Show SMILES COC(=O)C1=C(Nc2ccccn2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C19H14N4O4/c1-26-19(25)15-16(24)13(27-18(15)23-14-6-2-3-7-20-14)9-11-10-22-17-12(11)5-4-8-21-17/h2-10H,1H3,(H,20,23)(H,21,22)/b13-9-
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n/an/a 30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237678
PNG
(CHEMBL4082371)
Show SMILES COC(=O)C1=C(NCCc2ccccc2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C22H19N3O4/c1-28-22(27)18-19(26)17(12-15-13-25-20-16(15)8-5-10-23-20)29-21(18)24-11-9-14-6-3-2-4-7-14/h2-8,10,12-13,24H,9,11H2,1H3,(H,23,25)/b17-12-
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n/an/a 30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50574282
PNG
(CHEMBL4868568)
Show SMILES CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:5|
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n/an/a 30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP without preincubation

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01319
BindingDB Entry DOI: 10.7270/Q2CJ8J97
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50574282
PNG
(CHEMBL4868568)
Show SMILES CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:5|
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP with preincubation

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01319
BindingDB Entry DOI: 10.7270/Q2CJ8J97
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))		BDBM50237676
PNG
(CHEMBL4066501)
Show SMILES COC(=O)C1=C(Nc2ccc3ncccc3c2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
Show InChI InChI=1S/C23H16N4O4/c1-30-23(29)19-20(28)18(11-14-12-26-21-16(14)5-3-9-25-21)31-22(19)27-15-6-7-17-13(10-15)4-2-8-24-17/h2-12,27H,1H3,(H,25,26)/b18-11-
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n/an/a 36n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...

Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
BindingDB Entry DOI: 10.7270/Q2X63Q71
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))		BDBM50574282
PNG
(CHEMBL4868568)
Show SMILES CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:5|
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n/an/a 36n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of CDC7 in human SW-620 cells assessed as reduction in phosphorylation of MCM2 at Ser40 residue incubated for 48 hrs by Western blot analy...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01319
BindingDB Entry DOI: 10.7270/Q2CJ8J97
More data for this
Ligand-Target Pair
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