Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM50237989 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1662647 (CHEMBL4012328) | ||
IC50 | 12±n/a nM | ||
Citation | Graceffa, RF; Boezio, AA; Able, J; Altmann, S; Berry, LM; Boezio, C; Butler, JR; Chu-Moyer, M; Cooke, M; DiMauro, EF; Dineen, TA; Feric Bojic, E; Foti, RS; Fremeau, RT; Guzman-Perez, A; Gao, H; Gunaydin, H; Huang, H; Huang, L; Ilch, C; Jarosh, M; Kornecook, T; Kreiman, CR; La, DS; Ligutti, J; Milgram, BC; Lin, MJ; Marx, IE; Nguyen, HN; Peterson, EA; Rescourio, G; Roberts, J; Schenkel, L; Shimanovich, R; Sparling, BA; Stellwagen, J; Taborn, K; Vaida, KR; Wang, J; Yeoman, J; Yu, V; Zhu, D; Moyer, BD; Weiss, MM Sulfonamides as Selective Na J Med Chem60:5990-6017 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
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BDBM50237989 | |||
n/a | |||
Name | BDBM50237989 | ||
Synonyms: | CHEMBL4084372 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H22FN3O5S | ||
Mol. Mass. | 519.544 | ||
SMILES | COc1cc(c(C)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(C)c1 |(45.59,-10.99,;44.26,-11.77,;44.27,-13.31,;45.6,-14.07,;45.61,-15.62,;44.28,-16.39,;44.29,-17.93,;42.95,-15.63,;42.94,-14.09,;41.61,-13.33,;41.6,-11.78,;42.92,-11.01,;42.92,-9.48,;41.58,-8.72,;40.26,-9.49,;40.27,-11.01,;38.94,-11.78,;38.94,-13.33,;40.27,-14.1,;40.27,-15.64,;41.57,-7.17,;40.08,-6.77,;41.17,-5.68,;42.9,-6.4,;42.9,-4.86,;41.65,-3.96,;42.13,-2.49,;43.67,-2.49,;44.15,-3.96,;46.95,-16.38,;46.96,-17.92,;48.29,-18.69,;49.62,-17.91,;50.96,-18.67,;49.61,-16.36,;50.94,-15.58,;48.27,-15.61,)| | ||
Structure |