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TargetKynurenine 3-monooxygenase
LigandBDBM50072083
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1662733
IC50 20±n/a nM
Citation Liddle JBeaufils BBinnie MBouillot ADenis AAHann MMHaslam CPHolmes DSHutchinson JPKranz MMcBride AMirguet OMole DJMowat CGPal SRowland PTrottet LUings IJWalker ALWebster SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett 27:2023-2028 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine 3-monooxygenase
Name:Kynurenine 3-monooxygenase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:54371.88
Organism:Rattus norvegicus
Description:ChEMBL_1487468
Residue:478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50072083
n/a
NameBDBM50072083
Synonyms:CHEMBL3407929
TypeSmall organic molecule
Emp. Form.C11H8Cl2O3
Mol. Mass.259.085
SMILESOC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r|
Structure
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