Reaction Details |
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Target | Glutaminase liver isoform, mitochondrial |
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Ligand | BDBM50238207 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1663489 (CHEMBL4013170) |
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IC50 | 3778±n/a nM |
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Citation | Yeh, TK; Kuo, CC; Lee, YZ; Ke, YY; Chu, KF; Hsu, HY; Chang, HY; Liu, YW; Song, JS; Yang, CW; Lin, LM; Sun, M; Wu, SH; Kuo, PC; Shih, C; Chen, CT; Tsou, LK; Lee, SJ Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors. J Med Chem60:5599-5612 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase liver isoform, mitochondrial |
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Name: | Glutaminase liver isoform, mitochondrial |
Synonyms: | 3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase |
Type: | PROTEIN |
Mol. Mass.: | 66331.64 |
Organism: | Homo sapiens |
Description: | ChEMBL_117753 |
Residue: | 602 |
Sequence: | MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV
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BDBM50238207 |
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n/a |
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Name | BDBM50238207 |
Synonyms: | CHEMBL4100814 |
Type | Small organic molecule |
Emp. Form. | C22H13BrN2O2S3 |
Mol. Mass. | 513.45 |
SMILES | Brc1ccc(cc1)-n1c(cc(\C=C2/SC(=O)NC2=O)c1-c1cccs1)-c1cccs1 |
Structure |
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