Reaction Details |
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Target | Glutaminase kidney isoform, mitochondrial |
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Ligand | BDBM50400050 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1663490 (CHEMBL4013171) |
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IC50 | 81±n/a nM |
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Citation | Yeh, TK; Kuo, CC; Lee, YZ; Ke, YY; Chu, KF; Hsu, HY; Chang, HY; Liu, YW; Song, JS; Yang, CW; Lin, LM; Sun, M; Wu, SH; Kuo, PC; Shih, C; Chen, CT; Tsou, LK; Lee, SJ Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors. J Med Chem60:5599-5612 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase kidney isoform, mitochondrial |
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Name: | Glutaminase kidney isoform, mitochondrial |
Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
Type: | Protein |
Mol. Mass.: | 73471.89 |
Organism: | Homo sapiens (Human) |
Description: | O94925 |
Residue: | 669 |
Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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BDBM50400050 |
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n/a |
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Name | BDBM50400050 |
Synonyms: | CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732, Example BPTES | US8604016, 1 | US9938267, Cmpd ID 1 |
Type | Small organic molecule |
Emp. Form. | C24H24N6O2S3 |
Mol. Mass. | 524.681 |
SMILES | O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1 |
Structure |
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