| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM50239048 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1664960 (CHEMBL4014756) |
|---|
| EC50 | 0.800±n/a nM |
|---|
| Citation |  Xu, J; Lin, S; Myers, RW; Addona, G; Berger, JP; Campbell, B; Chen, HS; Chen, Z; Eiermann, GJ; Elowe, NH; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; Malkani, S; McMasters, DR; Mitra, K; Pachanski, MJ; Tong, X; Trujillo, ME; Xu, L; Zhang, B; Zhang, F; Zhang, R; Parmee, ER Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus. Bioorg Med Chem Lett27:2069-2073 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52175.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35557 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
|---|
| BDBM50239048 |
|---|
| n/a |
|---|
| Name | BDBM50239048 |
|---|
| Synonyms: | CHEMBL4067028 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22N4O4S |
|---|
| Mol. Mass. | 462.521 |
|---|
| SMILES | CN1C(CCC1=O)c1cc2[nH]c(cc2cc1Oc1ccc(nc1)S(C)(=O)=O)-c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
