Reaction Details |
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Target | Diacylglycerol O-acyltransferase 2 |
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Ligand | BDBM276754 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro DGAT2 Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 196±n/a nM |
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Comments | extracted |
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Citation | Boehm, M; Cabral, S; Dowling, MS; Futatsugi, K; Huard, K; Lee, EC; Londregan, AT; Polivkova, J; Price, DA; Li, Q Diacylglycerol acyl transferase 2 inhibitors US Patent US10071992 Publication Date 9/11/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 2 |
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Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM276754 |
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n/a |
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Name | BDBM276754 |
Synonyms: | N-(1,1-dioxidotetrahydro- thiophen-3-yl)-2-(5-((3- ethoxypyridin-2-yl)oxy) pyridin-3-yl)pyrimidine- 5-carboxamide | US10071992, Example 3.3 | US11034678, Example 3.3 | US11065249, WO2018033832-Ex.-3.3 | WO2018033832, Ex. 3.3 |
Type | Small organic molecule |
Emp. Form. | C21H21N5O5S |
Mol. Mass. | 455.487 |
SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1CCS(=O)(=O)C1 |
Structure |
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