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TargetL-lactate dehydrogenase A chain
LigandBDBM50219487
Substrate/Competitorn/a
Meas. Tech.Nuclear Magnetic Resonance (NMR) Assay
pH7.5±0
Temperature294.15±0 K
Kd 6.40e+5±n/a nM
Citation Ward, RA; Brassington, C; Breeze, AL; Caputo, A; Critchlow, S; Davies, G; Goodwin, L; Hassall, G; Greenwood, R; Holdgate, GA; Mrosek, M; Norman, RA; Pearson, S; Tart, J; Tucker, JA; Vogtherr, M; Whittaker, D; Wingfield, J; Winter, J; Hudson, K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem55:3285-306 (2012) [PubMed]  Article
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L-lactate dehydrogenase A chain
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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  Blast E-value cutoff:
BDBM50219487
n/a
NameBDBM50219487
Synonyms:1-hydroxy-2-naphthoate | 1-hydroxy-2-naphthoic acid | CHEMBL229299 | LDHA Inhibitor, 5 | NSC 3717 | Xinafoic acid
TypeSmall organic molecule
Emp. Form.C11H8O3
Mol. Mass.188.1794
SMILESOC(=O)c1ccc2ccccc2c1O
Structure
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