Reaction Details |
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Target | Serine/threonine-protein kinase receptor R3 |
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Ligand | BDBM280338 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases |
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IC50 | 8410±n/a nM |
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Citation | Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase receptor R3 |
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Name: | Serine/threonine-protein kinase receptor R3 |
Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
Type: | Enzyme |
Mol. Mass.: | 56134.46 |
Organism: | Homo sapiens (Human) |
Description: | P37023 |
Residue: | 503 |
Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
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BDBM280338 |
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n/a |
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Name | BDBM280338 |
Synonyms: | (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)pyridine-5-carboxamide | US10030004, Compound 3a | US10501436, Compound 3a | US11053216, Compound 3a | US11702401, Compound 3a |
Type | Small organic molecule |
Emp. Form. | C23H22ClFN4O2 |
Mol. Mass. | 440.898 |
SMILES | C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F |r| |
Structure |
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