| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
|---|
| Ligand | BDBM280355 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases |
|---|
| IC50 | 7290±n/a nM |
|---|
| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase receptor R3 |
|---|
| Name: | Serine/threonine-protein kinase receptor R3 |
|---|
| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56134.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37023 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
|
|
|
|---|
| BDBM280355 |
|---|
| n/a |
|---|
| Name | BDBM280355 |
|---|
| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]pyridine-3-carboxamide | US10030004, Compound 22 | US10501436, Compound 22 | US11053216, Compound 22 | US11702401, Compound 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24ClFN4O3 |
|---|
| Mol. Mass. | 458.913 |
|---|
| SMILES | CC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
