| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM280361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases |
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| IC50 | >100000±n/a nM |
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| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6:ALK6 | Activin receptor-like kinase 6 | Acvrlk6 | BMP type-1B receptor | BMPR-1B | BMR1B_MOUSE | Bmpr1b | SKR6 | Serine/threonine-protein kinase receptor R6 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56951.97 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P36898 |
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| Residue: | 502 |
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| Sequence: | MLLRSSGKLNVGTKKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVD
GPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM280361 |
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| n/a |
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| Name | BDBM280361 |
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| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-cyclopropyl-pyridine-3-carboxamide | US10030004, Compound 27 | US10501436, Compound 27 | US11053216, Compound 27 | US11702401, Compound 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20ClFN4O |
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| Mol. Mass. | 422.883 |
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| SMILES | CC(=C)c1cnc(cc1Nc1ccncc1C(=O)NC1CC1)-c1cc(Cl)ccc1F |
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| Structure | 
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