Ki Summary

Reaction Details

Report a problem with these data

Target

Renin

Ligand

BDBM98689

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

9.0±0.0 nM

Citation

Yokokawa, F; Ehara, T; Kawakami, S; Irie, O; Suzuki, M; Hitomi, Y; Toyao, A Organic compounds US Patent US8497286 Publication Date 7/30/2013

More Info.:

Get all data from this article, Assay Method

Renin

Name:

Renin

Synonyms:

Angiotensinogenase | REN | RENI_HUMAN

Type:

Enzyme

Mol. Mass.:

45058.99

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

406

Sequence:

MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

BDBM98689

n/a

Name

BDBM98689

Synonyms:

US8497286, 165

Type

Small organic molecule

Emp. Form.

C27H42N4O5

Mol. Mass.

502.6462

SMILES

COC[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1CNC[C@@H]([C@@H]1O)C(=O)N(C1CC1)c1cc(OC)c(cn1)C(C)C |r,wU:16.20,12.12,6.9,17.19,wD:3.2,(11.34,-2.21,;10,-1.44,;8.67,-2.21,;7.34,-1.44,;7.34,.1,;6,.87,;4.67,.1,;4.67,-1.44,;6,-2.21,;3.33,.87,;2,.1,;2,-1.44,;.67,.87,;.67,2.41,;-.67,3.18,;-2,2.41,;-2,.87,;-.67,.1,;-.67,-1.44,;-3.33,.1,;-3.33,-1.44,;-4.67,.87,;-4.67,2.41,;-3.9,3.75,;-5.44,3.75,;-6,.1,;-7.34,.87,;-8.67,.1,;-10,.87,;-10,2.41,;-8.67,-1.44,;-7.34,-2.21,;-6,-1.44,;-10,-2.21,;-11.34,-1.44,;-10,-3.75,)|

Structure