| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50382912 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Activity Assay |
|---|
| pH | 5.5±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | 0.5±0.0 nM |
|---|
| Citation |  Graham, TH; Liu, W; Sebhat, IK; Shen, D; Shi, Z Prolylcarboxypeptidase inhibitors US Patent US8569299 Publication Date 10/29/2013 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55805.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42785 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA
EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY
GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS
WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP
LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS
YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT
NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH
MKNWIRDFYDSAGKQH
|
|
|
|---|
| BDBM50382912 |
|---|
| n/a |
|---|
| Name | BDBM50382912 |
|---|
| Synonyms: | CHEMBL2023209 | US8569299, 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H34ClF3N4O |
|---|
| Mol. Mass. | 559.065 |
|---|
| SMILES | Cc1cc(C2CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)n(n1)-c1ccc(F)c(Cl)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
