| Reaction Details |
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 | Report a problem with these data |
| Target | Prunasin hydrolase |
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| Ligand | BDBM108220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay Against Commercial Glycosidases |
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| pH | 10.6±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 78±n/a nM |
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| Comments | extracted |
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| Citation |  Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease. Chembiochem14:1239-47 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prunasin hydrolase |
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| Name: | Prunasin hydrolase |
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| Synonyms: | β-glucosidase | Prunasin hydrolase |
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| Type: | Protein |
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| Mol. Mass.: | 61905.54 |
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| Organism: | Prunus dulcis (Almond) |
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| Description: | n/a |
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| Residue: | 544 |
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| Sequence: | MALQFRSLLLCMVLLLLGFALANTNAARTDPPIVCATLNRTHFDTLFPGFTFGAATAAYQ
LEGAANIDGRGPSVWDNFTHEHPEKITDGSNGDVAIDQYHRYKEDVAIMKDMGLDAYRFS
ISWSRLLPNGKLSGGINKKGIEYYNNLTNELLRNGIEPLVTLFHWDVPQALVDEYGGLLS
PRIVDDFKAYADLCYKEFGDRVKHWTTLNEPYTISNHGYTIGIHAPGRCSDWYNPKCLGG
DSGIEPYLVTHYLLLAHAAAVKLYREKYQAYQNGVIGITVVSHWFEPASESQQDKDAAFQ
ALDFMYGWFMDPLTRGDYPQIMRSILGARLPNFTEEQSKSLSGSYDYIGVNYYSARYASA
YPKDYSVTTPPSYLTDVHVNVTTDLNGVPIGPRAASDWLYVYPKGLYDLVLYTKEKYNDP
IMYITENGMDEFNNPKLSLEQALNDGNRIDYYYRHLCYLQAAMKEGANVQGYFAWSLLDN
FEWSEGYTVRFGINYIDYDNGLERHSKLSTHWFKSFLKRSSISKKKIRRCGNNNGRATKF
VYQI
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| BDBM108220 |
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| n/a |
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| Name | BDBM108220 |
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| Synonyms: | 5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 6) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N2O5 |
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| Mol. Mass. | 348.3936 |
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| SMILES | COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 |
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| Structure | 
|
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