| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Oligo-1,6-glucosidase IMA1 |
|---|
| Ligand | BDBM108221 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay Against Commercial Glycosidases |
|---|
| pH | 10.6±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 6±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease. Chembiochem14:1239-47 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Oligo-1,6-glucosidase IMA1 |
|---|
| Name: | Oligo-1,6-glucosidase IMA1 |
|---|
| Synonyms: | α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68577.59 |
|---|
| Organism: | Saccharomyces cerevisiae S288c (Baker's yeast) |
|---|
| Description: | n/a |
|---|
| Residue: | 589 |
|---|
| Sequence: | MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWIS
PFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWF
KESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCS
TQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQS
SDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSEL
FNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRF
GDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIK
EEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGIN
VEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAA
LNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
|
|
|
|---|
| BDBM108221 |
|---|
| n/a |
|---|
| Name | BDBM108221 |
|---|
| Synonyms: | 5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 7) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N2O4 |
|---|
| Mol. Mass. | 394.4635 |
|---|
| SMILES | OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12 |
|---|
| Structure | 
|
|---|
Search and Browse
