Reaction Details |
| Report a problem with these data |
Target | Transmembrane prolyl 4-hydroxylase |
---|
Ligand | BDBM109272 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
IC50 | 1.6e+3±n/a nM |
---|
Citation | Thede, K; Flamme, I; Oehme, F; Ergüden, J; Stoll, F; Wild, H; Kolkhof, P; Beck, H; Jeske, M Substituted dipyridyl-dihydropyrazolones and use thereof US Patent US8609698 Publication Date 12/17/2013 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Transmembrane prolyl 4-hydroxylase |
---|
Name: | Transmembrane prolyl 4-hydroxylase |
Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56654.25 |
Organism: | Homo sapiens (Human) |
Description: | Q9NXG6 |
Residue: | 502 |
Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
|
|
|
BDBM109272 |
---|
n/a |
---|
Name | BDBM109272 |
Synonyms: | US8609698, 80 |
Type | Small organic molecule |
Emp. Form. | C22H19N5O3 |
Mol. Mass. | 401.418 |
SMILES | Cc1ccccc1NC(=O)OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O |
Structure |
|