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Compile Data Set for Download or QSAR

Found 83 hits with Last Name = 'ergüden' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171626
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C35H34FN5O5S/c1-35(2,3)20-32(42)38-27-13-16-30-24(18-27)19-31(41(30)21-23-7-4-5-10-29(23)36)34(44)40-26-9-6-8-22(17-26)33(43)39-25-11-14-28(15-12-25)47(37,45)46/h4-19H,20-21H2,1-3H3,(H,38,42)(H,39,43)(H,40,44)(H2,37,45,46)
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n/an/a 39n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118338
PNG
(US8653111, 62)
Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3
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n/an/a 50n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171614
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CS(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3cc4cc(NC(=O)CC(C)(C)C)ccc4n3Cc3ccccc3F)c2)cc1
Show InChI InChI=1S/C36H35FN4O4S/c1-36(2,3)21-33(42)38-28-14-17-31-25(19-28)20-32(41(31)22-24-8-5-6-11-30(24)37)35(44)40-27-10-7-9-23(18-27)34(43)39-26-12-15-29(16-13-26)46(4)45/h5-20H,21-22H2,1-4H3,(H,38,42)(H,39,43)(H,40,44)
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n/an/a 66n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171633
PNG
(1-(2-Fluoro-benzyl)-5-[2-(1-methyl-cyclopentyl)-ac...)
Show SMILES CC1(CC(=O)Nc2ccc3n(Cc4ccccc4F)c(cc3c2)C(=O)Nc2ccccc2)CCCC1
Show InChI InChI=1S/C30H30FN3O2/c1-30(15-7-8-16-30)19-28(35)32-24-13-14-26-22(17-24)18-27(29(36)33-23-10-3-2-4-11-23)34(26)20-21-9-5-6-12-25(21)31/h2-6,9-14,17-18H,7-8,15-16,19-20H2,1H3,(H,32,35)(H,33,36)
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n/an/a 120n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171611
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C36H35FN4O5S/c1-36(2,3)21-33(42)38-28-14-17-31-25(19-28)20-32(41(31)22-24-8-5-6-11-30(24)37)35(44)40-27-10-7-9-23(18-27)34(43)39-26-12-15-29(16-13-26)47(4,45)46/h5-20H,21-22H2,1-4H3,(H,38,42)(H,39,43)(H,40,44)
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n/an/a 120n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171630
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc3cc(NC(=O)CC(C)(C)C)ccc3n2Cc2ccccc2F)cn1
Show InChI InChI=1S/C29H30FN5O3/c1-18(36)32-26-12-10-22(16-31-26)34-28(38)25-14-20-13-21(33-27(37)15-29(2,3)4)9-11-24(20)35(25)17-19-7-5-6-8-23(19)30/h5-14,16H,15,17H2,1-4H3,(H,33,37)(H,34,38)(H,31,32,36)
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n/an/a 130n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171629
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CNS(=O)(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3cc4cc(NC(=O)CC(C)(C)C)ccc4n3Cc3ccccc3F)c2)cc1
Show InChI InChI=1S/C36H36FN5O5S/c1-36(2,3)21-33(43)39-28-14-17-31-25(19-28)20-32(42(31)22-24-8-5-6-11-30(24)37)35(45)41-27-10-7-9-23(18-27)34(44)40-26-12-15-29(16-13-26)48(46,47)38-4/h5-20,38H,21-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)
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n/an/a 150n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171615
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccc(N)nc1
Show InChI InChI=1S/C27H28FN5O2/c1-27(2,3)14-25(34)31-19-8-10-22-18(12-19)13-23(26(35)32-20-9-11-24(29)30-15-20)33(22)16-17-6-4-5-7-21(17)28/h4-13,15H,14,16H2,1-3H3,(H2,29,30)(H,31,34)(H,32,35)
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n/an/a 170n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171613
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-trifluoromethyl...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3C(F)(F)F)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H28F3N3O2/c1-28(2,3)17-26(36)33-22-13-14-24-20(15-22)16-25(27(37)34-21-10-5-4-6-11-21)35(24)18-19-9-7-8-12-23(19)29(30,31)32/h4-16H,17-18H2,1-3H3,(H,33,36)(H,34,37)
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n/an/a 170n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3527
PNG
(US8524699, 18)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1
Show InChI InChI=1S/C16H16N6O2/c23-16-13(12-2-1-3-17-9-12)10-20-22(16)15-8-14(18-11-19-15)21-4-6-24-7-5-21/h1-3,8-11,20H,4-7H2
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n/an/a 180n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171824
PNG
(US9085572, 34)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-c2ccc(nc2)C#N)c1=O
Show InChI InChI=1S/C15H11N5O/c1-10-4-5-17-14(6-10)20-15(21)13(9-19-20)11-2-3-12(7-16)18-8-11/h2-6,8-9,19H,1H3
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n/an/a 180n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118341
PNG
(US8653111, 85)
Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N6O2/c1-15(2,3)10-23-11-4-5-13(16-8-11)21-14(22)12(9-18-21)20-7-6-17-19-20/h4-9,18H,10H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171643
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CCCCS(=O)(=O)Nc1ccc(NC(=O)c2cc3cc(NC(=O)CC(C)(C)C)ccc3n2Cc2ccccc2F)cc1
Show InChI InChI=1S/C32H37FN4O4S/c1-5-6-17-42(40,41)36-25-13-11-24(12-14-25)35-31(39)29-19-23-18-26(34-30(38)20-32(2,3)4)15-16-28(23)37(29)21-22-9-7-8-10-27(22)33/h7-16,18-19,36H,5-6,17,20-21H2,1-4H3,(H,34,38)(H,35,39)
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BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171628
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CN(C)C(=O)c1ccc(NC(=O)c2cc3cc(NC(=O)CC(C)(C)C)ccc3n2Cc2ccccc2F)cc1
Show InChI InChI=1S/C31H33FN4O3/c1-31(2,3)18-28(37)33-24-14-15-26-22(16-24)17-27(36(26)19-21-8-6-7-9-25(21)32)29(38)34-23-12-10-20(11-13-23)30(39)35(4)5/h6-17H,18-19H2,1-5H3,(H,33,37)(H,34,38)
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BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171637
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H28FN3O2/c1-28(2,3)17-26(33)30-22-13-14-24-20(15-22)16-25(27(34)31-21-10-5-4-6-11-21)32(24)18-19-9-7-8-12-23(19)29/h4-16H,17-18H2,1-3H3,(H,30,33)(H,31,34)
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BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171624
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccc(cc1)C(N)=O
Show InChI InChI=1S/C29H29FN4O3/c1-29(2,3)16-26(35)32-22-12-13-24-20(14-22)15-25(34(24)17-19-6-4-5-7-23(19)30)28(37)33-21-10-8-18(9-11-21)27(31)36/h4-15H,16-17H2,1-3H3,(H2,31,36)(H,32,35)(H,33,37)
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BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM109268
PNG
(US8609698, 10)
Show SMILES OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O
Show InChI InChI=1S/C14H9BrN4O3/c15-10-3-9(4-16-6-10)11-7-18-19(13(11)20)12-2-1-8(5-17-12)14(21)22/h1-7,18H,(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...

US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171612
PNG
(5-(2-Bicyclo[2.2.1]hept-2-yl-acetylamino)-1-(2-flu...)
Show SMILES Fc1ccccc1Cn1c(cc2cc(NC(=O)CC3CC4CCC3C4)ccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C31H30FN3O2/c32-27-9-5-4-6-22(27)19-35-28-13-12-26(33-30(36)18-23-15-20-10-11-21(23)14-20)16-24(28)17-29(35)31(37)34-25-7-2-1-3-8-25/h1-9,12-13,16-17,20-21,23H,10-11,14-15,18-19H2,(H,33,36)(H,34,37)
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BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118328
PNG
(US8653111, 7)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H10N6O/c1-8-2-3-12-10(6-8)17-11(18)9(7-14-17)16-5-4-13-15-16/h2-7,14H,1H3
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n/an/a 340n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118344
PNG
(US8653111, 103)
Show SMILES CCSc1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H11N7OS/c1-2-20-10-5-9(12-7-13-10)18-11(19)8(6-15-18)17-4-3-14-16-17/h3-7,15H,2H2,1H3
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n/an/a 350n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118346
PNG
(US8653111, 129)
Show SMILES CC1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C15H18N8O/c1-11-2-5-21(6-3-11)13-8-14(17-10-16-13)23-15(24)12(9-19-23)22-7-4-18-20-22/h4,7-11,19H,2-3,5-6H2,1H3
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n/an/a 360n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171631
PNG
(4-{[5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benz...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H28FN3O4/c1-29(2,3)16-26(34)31-22-12-13-24-20(14-22)15-25(33(24)17-19-6-4-5-7-23(19)30)27(35)32-21-10-8-18(9-11-21)28(36)37/h4-15H,16-17H2,1-3H3,(H,31,34)(H,32,35)(H,36,37)
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n/an/a 390n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171821
PNG
(US9085572, 6)
Show SMILES O=c1c(c[nH]n1-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-11(10-4-3-6-14-8-10)9-16-17(13)12-5-1-2-7-15-12/h1-9,16H
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n/an/a 430n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171642
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccc(Cl)nc1
Show InChI InChI=1S/C27H26ClFN4O2/c1-27(2,3)14-25(34)31-19-8-10-22-18(12-19)13-23(26(35)32-20-9-11-24(28)30-15-20)33(22)16-17-6-4-5-7-21(17)29/h4-13,15H,14,16H2,1-3H3,(H,31,34)(H,32,35)
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n/an/a 440n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3543
PNG
(US8524699, 16)
Show SMILES Clc1ccc(cn1)-c1c[nH]n(-c2cc(ncn2)N2CCOCC2)c1=O
Show InChI InChI=1S/C16H15ClN6O2/c17-13-2-1-11(8-18-13)12-9-21-23(16(12)24)15-7-14(19-10-20-15)22-3-5-25-6-4-22/h1-2,7-10,21H,3-6H2
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n/an/a 480n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118339
PNG
(US8653111, 72)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
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n/an/a 490n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118329
PNG
(US8653111, 10)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-n1ccnc1
Show InChI InChI=1S/C15H17N7O/c23-15-12(21-7-4-16-11-21)9-19-22(15)14-8-13(17-10-18-14)20-5-2-1-3-6-20/h4,7-11,19H,1-3,5-6H2
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n/an/a 500n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118331
PNG
(US8653111, 17)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)C1CC1)-n1ccnn1
Show InChI InChI=1S/C12H11N7O/c20-12-10(18-4-3-15-17-18)6-16-19(12)11-5-9(8-1-2-8)13-7-14-11/h3-8,16H,1-2H2
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n/an/a 560n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171632
PNG
(1-(2,6-Difluoro-benzyl)-5-(3,3-dimethyl-butyrylami...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3c(F)cccc3F)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H27F2N3O2/c1-28(2,3)16-26(34)31-20-12-13-24-18(14-20)15-25(27(35)32-19-8-5-4-6-9-19)33(24)17-21-22(29)10-7-11-23(21)30/h4-15H,16-17H2,1-3H3,(H,31,34)(H,32,35)
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n/an/a 650n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171616
PNG
(5-(3,3-Dimethyl-thiobutyrylamino)-1-(2-fluoro-benz...)
Show SMILES CC(C)(C)CC(=S)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H28FN3OS/c1-28(2,3)17-26(34)30-22-13-14-24-20(15-22)16-25(27(33)31-21-10-5-4-6-11-21)32(24)18-19-9-7-8-12-23(19)29/h4-16H,17-18H2,1-3H3,(H,30,34)(H,31,33)
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n/an/a 660n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118347
PNG
(US8653111, 166)
Show SMILES COC1CCCN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O
Show InChI InChI=1S/C16H19N7O2/c1-25-12-3-2-5-21(9-12)14-7-15(19-10-18-14)23-16(24)13(8-20-23)22-6-4-17-11-22/h4,6-8,10-12,20H,2-3,5,9H2,1H3
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n/an/a 690n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3555
PNG
(US8524699, 3)
Show SMILES Cc1cc(C)n(n1)-c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C17H15N7O/c1-11-6-12(2)23(22-11)15-7-16(20-10-19-15)24-17(25)14(9-21-24)13-4-3-5-18-8-13/h3-10,21H,1-2H3
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n/an/a 700n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171827
PNG
(US9085572, 46)
Show SMILES O=C(Cc1ccccc1)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O2/c28-21(12-16-5-2-1-3-6-16)25-13-17-8-10-24-20(11-17)27-22(29)19(15-26-27)18-7-4-9-23-14-18/h1-11,14-15,26H,12-13H2,(H,25,28)
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n/an/a 700n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171640
PNG
(5-(4,4-Dimethyl-pentanoylamino)-1-(2-fluoro-benzyl...)
Show SMILES CC(C)(C)CCC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H30FN3O2/c1-29(2,3)16-15-27(34)31-23-13-14-25-21(17-23)18-26(28(35)32-22-10-5-4-6-11-22)33(25)19-20-9-7-8-12-24(20)30/h4-14,17-18H,15-16,19H2,1-3H3,(H,31,34)(H,32,35)
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n/an/a 740n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118345
PNG
(US8653111, 113)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCSCC1)-n1ccnn1
Show InChI InChI=1S/C13H14N8OS/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
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n/an/a 740n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118330
PNG
(US8653111, 12)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H10F3N5O2/c14-13(15,16)10-5-20(7-18-10)9-4-19-21(12(9)23)11-2-1-8(6-22)3-17-11/h1-5,7,19,22H,6H2
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n/an/a 750n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171823
PNG
(US9085572, 26)
Show SMILES Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C14H12N4O/c1-10-11(5-4-8-15-10)12-9-17-18(14(12)19)13-6-2-3-7-16-13/h2-9,17H,1H3
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n/an/a 760n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118333
PNG
(US8653111, 45)
Show SMILES CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O
Show InChI InChI=1S/C14H16N6O2/c1-9(2)11-7-19(18-17-11)12-6-16-20(14(12)22)13-4-3-10(8-21)5-15-13/h3-7,9,16,21H,8H2,1-2H3
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n/an/a 780n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171638
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C27H27FN4O2/c1-27(2,3)15-25(33)30-20-10-11-23-19(13-20)14-24(26(34)31-21-8-6-12-29-16-21)32(23)17-18-7-4-5-9-22(18)28/h4-14,16H,15,17H2,1-3H3,(H,30,33)(H,31,34)
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n/an/a 850n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171621
PNG
(1-Cyclohexylmethyl-5-(3,3-dimethyl-butyrylamino)-1...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(CC3CCCCC3)c(cc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H35N3O2/c1-28(2,3)18-26(32)29-23-14-15-24-21(16-23)17-25(27(33)30-22-12-8-5-9-13-22)31(24)19-20-10-6-4-7-11-20/h5,8-9,12-17,20H,4,6-7,10-11,18-19H2,1-3H3,(H,29,32)(H,30,33)
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n/an/a 860n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM171822
PNG
(US9085572, 23)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H12N4O2/c19-9-10-3-4-13(16-6-10)18-14(20)12(8-17-18)11-2-1-5-15-7-11/h1-8,17,19H,9H2
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n/an/a 860n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US9085572 (2015)


BindingDB Entry DOI: 10.7270/Q2H70DMQ
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3591
PNG
(US8524699, 7)
Show SMILES Clc1ccc(cc1)-c1nnc(s1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H10ClN5OS/c17-12-5-3-10(4-6-12)14-20-21-16(24-14)22-15(23)13(9-19-22)11-2-1-7-18-8-11/h1-9,19H
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n/an/a 880n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3623
PNG
(US8524699, 28)
Show SMILES COCCN1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C19H23N7O2/c1-28-10-9-24-5-7-25(8-6-24)17-11-18(22-14-21-17)26-19(27)16(13-23-26)15-3-2-4-20-12-15/h2-4,11-14,23H,5-10H2,1H3
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n/an/a 890n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM109271
PNG
(US8609698, 65)
Show SMILES Clc1cccc(Cl)c1NC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C21H16Cl2N6O2/c22-16-4-1-5-17(23)19(16)28-21(31)26-10-13-6-8-25-18(9-13)29-20(30)15(12-27-29)14-3-2-7-24-11-14/h1-9,11-12,27H,10H2,(H2,26,28,31)
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n/an/a 900n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...

US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM109269
PNG
(US8609698, 18)
Show SMILES CC(C)(C)NC(=O)c1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H19N5O2/c1-18(2,3)22-16(24)13-6-7-15(20-10-13)23-17(25)14(11-21-23)12-5-4-8-19-9-12/h4-11,21H,1-3H3,(H,22,24)
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n/an/a 910n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...

US Patent US8609698 (2013)


BindingDB Entry DOI: 10.7270/Q2G44NZ8
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3629
PNG
(US8524699, 46)
Show SMILES O=c1c(c[nH]n1-c1cnccn1)-c1cccnc1
Show InChI InChI=1S/C12H9N5O/c18-12-10(9-2-1-3-13-6-9)7-16-17(12)11-8-14-4-5-15-11/h1-8,16H
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n/an/a 930n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118337
PNG
(US8653111, 61)
Show SMILES Cc1cc(ncc1Br)-n1[nH]cc(-n2ccnn2)c1=O
Show InChI InChI=1S/C11H9BrN6O/c1-7-4-10(13-5-8(7)12)18-11(19)9(6-15-18)17-3-2-14-16-17/h2-6,15H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase


(Homo sapiens (Human))		BDBM3643
PNG
(US8524699, 44)
Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-c1cncc(c1)C#N
Show InChI InChI=1S/C18H17N7O/c19-8-13-6-14(10-20-9-13)15-11-23-25(18(15)26)17-7-16(21-12-22-17)24-4-2-1-3-5-24/h6-7,9-12,23H,1-5H2
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n/an/a 1.12E+3n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.

US Patent US8524699 (2013)


BindingDB Entry DOI: 10.7270/Q2TB15J4
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Homo sapiens (Human))		BDBM50171641
PNG
(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccc(N)cn1
Show InChI InChI=1S/C27H28FN5O2/c1-27(2,3)14-25(34)31-20-9-10-22-18(12-20)13-23(26(35)32-24-11-8-19(29)15-30-24)33(22)16-17-6-4-5-7-21(17)28/h4-13,15H,14,16,29H2,1-3H3,(H,31,34)(H,30,32,35)
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n/an/a 1.20E+3n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrate

Bioorg Med Chem Lett 15: 4201-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.085
BindingDB Entry DOI: 10.7270/Q2H994R9
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM118336
PNG
(US8653111, 60)
Show SMILES CCc1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O
Show InChI InChI=1S/C13H11F3N6O/c1-2-8-3-11(18-6-17-8)22-12(23)9(4-20-22)21-5-10(19-7-21)13(14,15)16/h3-7,20H,2H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...

US Patent US8653111 (2014)


BindingDB Entry DOI: 10.7270/Q2GH9GMD
More data for this
Ligand-Target Pair
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