| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase CSK |
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| Ligand | BDBM110212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | c-Src Kinase Inhibitory Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 2.48e+4±n/a nM |
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| Comments | extracted |
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| Citation |  Chand, K; Prasad, S; Tiwari, RK; Shirazi, AN; Kumar, S; Parang, K; Sharma, SK Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorg Chem53:75-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase CSK |
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| Name: | Tyrosine-protein kinase CSK |
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| Synonyms: | C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 50707.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41240 |
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| Residue: | 450 |
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| Sequence: | MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
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| BDBM110212 |
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| n/a |
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| Name | BDBM110212 |
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| Synonyms: | 1-Cyclohexyl-5-(2-hydroxy-5-methoxybenzoyl)pyridin-2 (1H)-one (42) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO4 |
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| Mol. Mass. | 327.3743 |
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| SMILES | COc1ccc(O)c(c1)C(=O)c1ccc(=O)n(c1)C1CCCCC1 |
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| Structure | 
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