| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-glucosidase MAL12 |
|---|
| Ligand | BDBM112646 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Glucosidase assay |
|---|
| pH | 6.8±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 1.1221e+5± 9.7e+2 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Yar, M; Bajda, M; Shahzadi, L; Shahzad, SA; Ahmed, M; Ashraf, M; Alam, U; Khan, IU; Khan, AF Novel synthesis of dihydropyrimidines for a-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking. Bioorg Chem54:96-104 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-glucosidase MAL12 |
|---|
| Name: | Alpha-glucosidase MAL12 |
|---|
| Synonyms: | α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68084.32 |
|---|
| Organism: | Saccharomyces cerevisiae |
|---|
| Description: | P53341 |
|---|
| Residue: | 584 |
|---|
| Sequence: | MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCP
FYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFK
ESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASR
QVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHP
NWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSF
THVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADD
SPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSF
GKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQ
ESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNF
SGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
|
|
|
|---|
| BDBM112646 |
|---|
| n/a |
|---|
| Name | BDBM112646 |
|---|
| Synonyms: | Ethyl 6-methyl-4-(4-methylphenyl)-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carboxylate (4f) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18N2O3 |
|---|
| Mol. Mass. | 274.315 |
|---|
| SMILES | CCOC(=O)C1C(NC(=O)N=C1C)c1ccc(C)cc1 |c:10| |
|---|
| Structure | 
|
|---|
Search and Browse
