Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM118590 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay |
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Ki | 16±n/a nM |
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Citation | Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Soyode-Johnson, A; Stocking, EM; Swanson, DM Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators US Patent US8653263 Publication Date 2/18/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM118590 |
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n/a |
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Name | BDBM118590 |
Synonyms: | US11059828, Example 243 | US11667644, Example 243 | US8653263, 243 | US9586962, Example 243 | USRE48841, Example 243 |
Type | Small organic molecule |
Emp. Form. | C25H20F2N6O |
Mol. Mass. | 458.4627 |
SMILES | Fc1ccc2nc(ncc2c1)N1CC2CN(CC2C1)C(=O)c1cccc(F)c1-c1ncccn1 |
Structure |
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