| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 4 |
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| Ligand | BDBM124260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PTP inhibition assay |
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| pH | 7.2±n/a |
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| IC50 | 9.7e+2± 6e+3 nM |
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| Comments | extracted |
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| Citation |  Han, H; Lu, L; Wang, Q; Zhu, M; Yuan, C; Xing, S; Fu, X Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B. Dalton Trans41:11116-24 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 4 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 4 |
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| Synonyms: | Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2) | PTN4_HUMAN | PTPN4 | Protein-tyrosine phosphatase MEG1 | Tyrosine-protein phosphatase non-receptor type 4 (PTP-MEG1) |
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| Type: | Protein |
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| Mol. Mass.: | 105923.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 926 |
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| Sequence: | MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK
HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE
YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ
PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG
ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA
CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS
KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV
DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY
SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM
PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL
VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD
QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII
NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ
VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK
RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ
YRFVCEAILKVYEEGFVKPLTTSTNK
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| BDBM124260 |
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| n/a |
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| Name | BDBM124260 |
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| Synonyms: | 2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua-oxovanadium(IV) (1) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12BrNO6V |
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| Mol. Mass. | 421.093 |
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| SMILES | [OH2+][V]12([OH2+])(=O)OC(=O)c3ccccc3[N]1=Cc1cc(Br)ccc1O2 |c:15| |
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| Structure | 
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