| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 4 |
|---|
| Ligand | BDBM124263 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PTP inhibition assay |
|---|
| pH | 7.2±n/a |
|---|
| IC50 | 2.9e+3± 4e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Han, H; Lu, L; Wang, Q; Zhu, M; Yuan, C; Xing, S; Fu, X Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B. Dalton Trans41:11116-24 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 4 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 4 |
|---|
| Synonyms: | Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2) | PTN4_HUMAN | PTPN4 | Protein-tyrosine phosphatase MEG1 | Tyrosine-protein phosphatase non-receptor type 4 (PTP-MEG1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 105923.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 926 |
|---|
| Sequence: | MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK
HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE
YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ
PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG
ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA
CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS
KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV
DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY
SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM
PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL
VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD
QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII
NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ
VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK
RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ
YRFVCEAILKVYEEGFVKPLTTSTNK
|
|
|
|---|
| BDBM124263 |
|---|
| n/a |
|---|
| Name | BDBM124263 |
|---|
| Synonyms: | Bis(4-bromo-2-((phenylimino)methyl)phenolate)-oxovanadium(IV) (4) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H18Br2N2O3V |
|---|
| Mol. Mass. | 617.182 |
|---|
| SMILES | Brc1ccc2O[V]3(=O)(Oc4ccc(Br)cc4C=[N]3c3ccccc3)[N](=Cc2c1)c1ccccc1 |c:17,27| |
|---|
| Structure | 
|
|---|
Search and Browse
