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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | High affinity nerve growth factor receptor | ||
| Ligand | BDBM127661 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ELISA Assay | ||
| pH | 7.5±n/a | ||
| IC50 | 1.1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US8791123 Publication Date 7/29/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| High affinity nerve growth factor receptor | |||
| Name: | High affinity nerve growth factor receptor | ||
| Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA | ||
| Type: | n/a | ||
| Mol. Mass.: | 87498.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04629 | ||
| Residue: | 796 | ||
| Sequence: |
| ||
| BDBM127661 | |||
| n/a | |||
| Name | BDBM127661 | ||
| Synonyms: | US8791123, 34 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28FN5O3 | ||
| Mol. Mass. | 453.5092 | ||
| SMILES | OCc1ccc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CCC(O)CC3)c2n1 |(-6.64,.74,;-7.04,2.23,;-5.95,3.32,;-6.35,4.81,;-5.26,5.9,;-3.77,5.5,;-2.68,6.59,;-3.37,4.01,;-4.46,2.92,;-4.06,1.43,;-4.97,.19,;-4.06,-1.06,;-2.6,-.58,;-2.6,.96,;-1.26,1.73,;-1.26,3.27,;.07,4.04,;1.4,3.27,;2.87,3.74,;3.77,2.5,;2.87,1.25,;3.27,-.24,;2.18,-1.33,;4.75,-.64,;5.15,-2.12,;4.06,-3.21,;4.46,-4.7,;5.95,-5.1,;6.35,-6.59,;7.04,-4.01,;6.64,-2.52,;1.4,1.73,;.07,.96,)| | ||
| Structure | 
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