Reaction Details |
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Target | Mast/stem cell growth factor receptor Kit |
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Ligand | BDBM4881 |
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Substrate/Competitor | poly(Glu:Tyr) |
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Meas. Tech. | PDGFR-beta Inhibition Assay |
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IC50 | >10000±n/a nM |
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Citation | Bold, G; Altmann, KH; Frei, J; Lang, M; Manley, PW; Traxler, P; Wietfeld, B; Bruggen, J; Buchdunger, E; Cozens, R; Ferrari, S; Furet, P; Hofmann, F; Martiny-Baron, G; Mestan, J; Rosel, J; Sills, M; Stover, D; Acemoglu, F; Boss, E; Emmenegger, R; Lasser, L; Masso, E; Roth, R; Schlachter, C; Vetterli, W New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J Med Chem43:2310-23 (2000) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Mast/stem cell growth factor receptor Kit |
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Name: | Mast/stem cell growth factor receptor Kit |
Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Type: | Protein |
Mol. Mass.: | 109869.37 |
Organism: | Homo sapiens (Human) |
Description: | P10721 |
Residue: | 976 |
Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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BDBM4881 |
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poly(Glu:Tyr) |
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Name: | poly(Glu:Tyr) |
Synonyms: | n/a |
Type: | Random Copolymer |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | polyGluTyr(4:1).
1 uM ATP and 0.2 uCi [gamma-33P]ATP as co-substrate. |
Residue: | 3 |
Sequence: | |