| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 [T412E] |
|---|
| Ligand | BDBM224336 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | P70S6K Enzyme Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 7.20±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent US10080750 Publication Date 9/25/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ribosomal protein S6 kinase beta-1 [T412E] |
|---|
| Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
|---|
| Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 59166.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23443[T412E] |
|---|
| Residue: | 525 |
|---|
| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
|
|
|
|---|
| BDBM224336 |
|---|
| n/a |
|---|
| Name | BDBM224336 |
|---|
| Synonyms: | US10080750, Compound 13 | US9321760, 13 | US9662330, Compound 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21F4N5 |
|---|
| Mol. Mass. | 431.4293 |
|---|
| SMILES | Nc1ncnc(N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c1-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
