| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Ligand | BDBM224376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P70S6K Enzyme Assay |
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| pH | 7.5±n/a |
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| IC50 | 3.20±n/a nM |
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| Comments | extracted |
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| Citation |  Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent US10080750 Publication Date 9/25/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 [T412E] |
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| Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59166.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23443[T412E] |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM224376 |
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| n/a |
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| Name | BDBM224376 |
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| Synonyms: | US10080750, Compound 53 | US9321760, 53 | US9662330, Compound 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25F4N5 |
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| Mol. Mass. | 459.4824 |
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| SMILES | NC[C@@H](C1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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