Reaction Details |
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Target | Metallo-beta-lactamase VIM-2 |
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Ligand | BDBM153701 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Direct Competition Assay |
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Ki | 1.4e+4± 1e+3 nM |
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Citation | Mojica, MF; Mahler, SG; Bethel, CR; Taracila, MA; Kosmopoulou, M; Papp-Wallace, KM; Llarrull, LI; Wilson, BM; Marshall, SH; Wallace, CJ; Villegas, MV; Harris, ME; Vila, AJ; Spencer, J; Bonomo, RA Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry54:3183-96 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Metallo-beta-lactamase VIM-2 |
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Name: | Metallo-beta-lactamase VIM-2 |
Synonyms: | Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2) |
Type: | Protein |
Mol. Mass.: | 28318.00 |
Organism: | Pseudomonas aeruginosa (g-Proteobacteria) |
Description: | n/a |
Residue: | 266 |
Sequence: | MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQ
SFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRV
GGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHS
TDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGH
GLPGGLDLLKHTTNVVKAHTNRSVVE
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BDBM153701 |
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n/a |
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Name | BDBM153701 |
Synonyms: | D-VC26 |
Type | Small organic molecule |
Emp. Form. | C9H15NO2S3 |
Mol. Mass. | 265.416 |
SMILES | CC1(C)S[C@@H]2CS[C@@H](CS)N2[C@H]1C(O)=O |r| |
Structure |
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