| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase UHRF1 |
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| Ligand | BDBM154556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| pH | 8±0 |
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| Temperature | 1663.9±0 K |
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| IC50 | >1.00e+5±n/a nM |
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| Citation |  Perfetti, MT; Baughman, BM; Dickson, BM; Mu, Y; Cui, G; Mader, P; Dong, A; Norris, JL; Rothbart, SB; Strahl, BD; Brown, PJ; Janzen, WP; Arrowsmith, CH; Mer, G; McBride, KM; James, LI; Frye, SV Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol10:1072-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| E3 ubiquitin-protein ligase UHRF1 |
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| Name: | E3 ubiquitin-protein ligase UHRF1 |
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| Synonyms: | 6.3.2.- | E3 ubiquitin-protein ligase (UHRF1) | E3 ubiquitin-protein ligase UHRF1 | HuNp95 | ICBP90 | Inverted CCAAT box-binding protein of 90 kDa | NP95 | Nuclear protein 95 | Nuclear zinc finger protein Np95 | RING finger protein 106 | RNF106 | Transcription factor ICBP90 | UHRF1 | UHRF1_HUMAN | Ubiquitin-like PHD and RING finger domain-containing protein 1 | Ubiquitin-like-containing PHD and RING finger domains protein 1 | hNp95 | hUHRF1 |
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| Type: | Protein |
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| Mol. Mass.: | 89822.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 793 |
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| Sequence: | MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFD
YEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSR
PADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEE
DVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYD
AEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGP
SCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYC
PECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGP
IPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTG
SGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVK
GGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKK
LGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAG
SPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEE
TFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQT
VLNQLFPGYGNGR
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| BDBM154556 |
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| n/a |
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| Name | BDBM154556 |
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| Synonyms: | 3-Bromo-N-(5-(tert-butylamino)pentyl)benzamide (12) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H25BrN2O |
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| Mol. Mass. | 341.286 |
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| SMILES | CC(C)(C)NCCCCCNC(=O)c1cccc(Br)c1 |
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| Structure | 
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